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عمومی::
جریان خون مغزی
CHEMICAL REGULATION OF CEREBRAL BLOOD FLOW
Several factors, including changes in CMR, arterial partial pressure of carbon dioxide (Paco2), and arterial partial pres- sure of oxygen (Pao2) cause alterations in the cerebral bio- chemical environment that result in adjustments in CBF.
Regional CBF and metabolism are tightly coupled.
Increased neuronal activity results in increased local brain metabolism, and this increase in the CMR is associated with a proportional change in CBF referred to as neurovascular coupling.
traditional view of neurovascular coupling is that it is a positive feedback mechanism wherein increased neuro- nal activity results in a demand for energy; this demand is met by an increase in CBF.
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